Pain type guides medication prescribed

Somatic (nociceptive) pain: Acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs caution in older adults) and opioids (long-acting preferred); trial of adjuvants (see Table 2) for refractory symptoms.

Neuropathic pain: Serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), anticonvulsants, lidocaine patch, tramadol and opioids. (SSRIs and NSAIDs often ineffective.)

Centralized pain/Fibromyalgia: TCAs (amitriptyiline, cyclobenzaprine), SNRIs (duloxetine) and alpha-2-delta ligands (pregabalin and gabapentin) are effective for conditions such as fibromyalgia. Serotonin-selective reuptake inhibitors (SSRIs) can also be useful. (Opioids are not indicated.)

Understanding Opioid Pain Medications


 If opioid analgesics have been used or are being considered, dependence and addiction risk should be assessed through careful personal and family history, review of outside records and assessment of illicit or prescription medication misuse. Check your State’s prescription monitoring program (PMP) and perform a urine screen by combination of enzyme immunolinked assay (EIA) and gas chromatography/mass spectroscopy (GCMS) prior to prescribing and at least yearly for patients given chronic opioid therapy. [ID]* 

If initiating opioid therapy:
Assess risk for addiction (see Table 3)
Present opioids as a tool to help reach functional improvement goals; be clear that opioids will be continued
only if they
contribute to functional improvement or maintenance
Establish prescribing practices: one prescriber/one pharmacy, no after-hours refills, no early refills without appointment,

compliance with adjuvant therapies, no Emergency Department visits for pain medications, random urine drug screens, required follow-up  at  scheduled  intervals.    See  model  “Controlled  Substance  Treatment  Agreement”  in  Appendix  C.

 



For patients being considered for, or already receiving, chronic daily opioid therapy: check comprehensive drug screen = EIA + GCMS (at UM = DRUG COMP = Drug6 (i.e. EIA) + GCMS) and search State prescription monitoring programs (PMP) for opioid prescriptions (e.g., MAPS search in Michigan [https://sso.state.mi.us], OARRS in Ohio [www.ohiopmp.gov]).